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Customized Vitamin


Item Details:

  • Street: DSASAS
  • City: Churchill
  • Province: Manitoba
  • Expires: 61 days, 15 hours

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  • Item listed by: on February 20, 2019

    Item Description:

    Tocofersolan CAS NO. 9002-96-4 (USP39) is off-white or yellowish waxy solid, completely dissolves in water to form a clear, clear solution. The maximum solubility of water-soluble natural VE in water is about 20%. Above this concentration, a crystalline liquid is formed in the aqueous solution.
    Quick Details
    Product NameTocofersolan
    Other NameTocopherosolan;TPGS;
    D-alpha-Tocopheryl polyethylene glycol succinate
    CAS No.9002-96-4
    AppearanceOff-white or yellowish waxy solid
    D -α-tocopheryl polyethylene glycol 1000 succinate is a water-soluble derivative of natural-source vitamin E. Off-white or yellowish waxy solid, almost tasteless, soluble in water and most of the polar organic solvents such as ethanol. It is amphipathic, miscible with water, and forms a variety of liquid crystalline phases in water. The excipient melts at 37–41℃ and is heat stable at temperatures ≤200℃.
    1) As a solubilizer:
    TPGS increases the permeability of amprenavir by inhibiting efflux. Amprenavir is a new HIV protease inhibitor. At present, Amprenavir products which use TPGS as an excipient are currently available in the United States, such as Agenerase ™ oral liquid and capsules. It has also been reported that micellar solubilization of TPGS increases estradiol solubility and transdermal permeation. After combined with cyclosporine A, TPGS increased the solubility of cyclosporine A, thereby enhancing the cyclosporine A bioavailability.
    2) Apply to solid dispersion technology:
    Water-soluble excipient such as lactose, mannitol, hydroxypropyl methyl cellulose and the like are added into the TPGS drug mixture to accelerate drug release. Adding hydrophobic materials, such as wax, can slow down dissolution. In addition, an expansiveness excipient can be added at the bottom of the capsule, and then expanded after exposure to water thus pushing the liquid crystal matrix into the intestinal tract.
    3) As a plasticizer:
    TPGS as a plasticizer reduce the interaction among the polymer molecules, so that the polymer chains are more likely to move. It provides polymer molecules with greater freedom mobile space, allowing more stretching and elastic membrane.
    4) As an emulgator:
    TPGS is amphiphilic. Experiments show that both in water and oil phase, TPGS has such high entrapment efficiency.
    5) As a sorbefacient:
    TPGS can improve gastrointestinal absorption of animals and people.
    6) Others:
    TPGS is waxy solid at room temperature. As an ophthalmic preparation, the viscosity is high which can extend the residence time on the surface of the cornea, reduce the stimulus and significantly increase the solubility of indissolvable drug in the eye. As a surfactant, it can make sprays from Glucocorticoid Beclometasone Dipropionate and treat respiratory illness through nasal drug delivery.
    Quality Control
    Reputation First! Quality First!
    We are responsible for products returning and refunding for any quality problem! We accept third party inspection like SGS, BV and TUV.
    Vitamin E

    Succinic anhydride、Triethylamine、Petroleum ether Esterification reaction
    Vitamin E Succinate
    Ethanol Refine

    PEG1000、Toulene、P-toluenesulfonic Esterification
    Vitamin E TPGS
    Ethanol Refine
    Customized Vitamin

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    20 total views, 1 today


    Listing ID: 8305c6d172b0ac2b

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